Abstract: Analysis of Correlated Factors of Ovarian Metastasis in 380 Colorectal Cancer CasesShen HUANG , Sen ZHANG, Feng GAO, Chuanyuan LIU, Jungang LIUCorrespondence to: Sen ZHANG, E-mail: zs0771@hotmail.comDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, ChinaThis work was supported by National Natural Science Foundation of China (No. 30560150, 30672059); Science Research Project ofHealth Department of the Guangxi Zhuang Autonomous Region (No. 200404); and Innovation Project of Guangxi Graduate Education(No. 2009105981002M200, 2008105981002M194)Abstract Objective: To investigate the clinicopathologic factors related to ovarian metastasis in 380 colorectal cancer cases.Methods: Clinicopathologic data from a total of 380 patients with colorectal cancer treated in our hospital between January 2004 andFebruary 2009 were collected. Parameters that were examined included mesomorphic phase, disease course, primary symptoms, tumorlocation, tumor size (cm), peritoneal reflection, tumor circumference, tumor gross type, histological type, grade of tumor differentiation,depth of invasion, N status, total protein levels, ALB levels, FOBT, and serum CEA levels. Univariate and multivariate analyses wereused to evaluate the relevant factors by Binary logistic regression (SPSS 13.0 for windows). Results: Of the 380 cases, 54 (14.2%) cas-es had ovarian metastases. Mesomorphic phase, disease course, primary symptoms, tumor size (cm), tumor circumference, histologicaltype, grade of tumor differentiation, depth of invasion and serum CEA levels were found to be predictors that could affect ovarian me-tastasis in univariate analysis. Mesomorphic phase, primary symptoms, tumor circumference, histological type, grade of tumor differen-tiation, and serum CEA levels were independent risk factors related with colorectal ovarian metastasis in multivariate analysis. Conclu-sion: Mesomorphic phase, primary symptoms, tumor circumference, histological type, grade of tumor differentiation, and serum CEAlevel were the clinicopathologic factors related to ovarian metastasis from colorectal carcinoma.Keywords Colorectal neoplasm; Ovarian metastasis; Univarate analysis; Multivariate analysis